saikosaponin A, saikosaponin B, saikosaponin B1, saikosaponin B2, saikosaponin B3, saikosaponin B4, saikosaponin C, saikosaponin D, saikosaponin K, saikosaponin L, saikosaponins
| Name | Saikosaponin B1 | ||
| PubChem CID | 9875547 | ||
| Molecular Weight | 781.0g/mol | ||
| Synonyms |
saikosaponin A, saikosaponin B, saikosaponin B1, saikosaponin B2, saikosaponin B3, saikosaponin B4, saikosaponin C, saikosaponin D, saikosaponin K, saikosaponin L, saikosaponins |
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| Formula | C₄₂H₆₈O₁₃ | ||
| SMILES | CC1C(C(C(C(O1)OC2CCC3(C(C2(C)CO)CCC4(C3C=CC5=C6CC(CCC6(C(CC54C)O)CO)(C)C)C)C)O)OC7C(C(C(C(O7)CO)O)O)O)O | ||
| InChI | 1S/C42H68O13/c1-21-29(47)34(55-35-32(50)31(49)30(48)24(18-43)53-35)33(51)36(52-21)54-28-11-12-38(4)25(39(28,5)19-44)10-13-40(6)26(38)9-8-22-23-16-37(2,3)14-15-42(23,20-45)27(46)17-41(22,40)7/h8-9,21,24-36,43-51H,10-20H2,1-7H3/t21-,24-,25-,26-,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,38+,39+,40-,41-,42-/m1/s1 | ||
| InChIKey | WRYJYFCCMSVEPQ-MNIDVGFKSA-N | ||
| CAS Number | 58558-08-0 | ||
| ChEMBL ID | CHEMBL3613729 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ChaiHu | ||
| Use Part | Root | ||
| Habitat | HuBei, SiChuan, AnHui | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Gallbladder, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Bupleurum
-->Species: Bupleurum scorzonerifolium
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| Chineses Pinyin | QianHu | ||
| Use Part | Root | ||
| Habitat | ZheJiang, HuNan, SiChuan | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Lung | ||
| Chineses Pinyin | XiaoYeHeiChaiHu | ||
| Use Part | Root | ||
| Habitat | NeiMengGu, GanSu, NingXia, QingHai | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Heart, Liver, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Bupleurum
-->Species: Bupleurum smithii
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| Pair Name | Saikosaponin B1, Etoposide | |||
| Partner Name | Etoposide | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Down-regulation | Activity | NFKB1 | hsa4790 |
| Up-regulation | Expression | H2AX | hsa3014 | |
| In Vitro Model | B16-F10 | Mouse melanoma | Mus musculus (Mouse) | CVCL_0159 |
| Result | We conclude Saikosaponin B can be an attractive adjuvant for enhancing the clinical effect of cancer chemotherapy. | |||
